Defining the Molecular Mechanisms of the Relaxant Action of Adiponectin on Murine Gastric Fundus Smooth Muscle: Potential Translational Perspectives on Eating Disorder Management
-
Published:2023-01-05
Issue:2
Volume:24
Page:1082
-
ISSN:1422-0067
-
Container-title:International Journal of Molecular Sciences
-
language:en
-
Short-container-title:IJMS
Author:
Garella Rachele, Cassioli EmanueleORCID, Chellini Flaminia, Tani Alessia, Rossi EleonoraORCID, Idrizaj EglantinaORCID, Guasti Daniele, Comeglio Paolo, Palmieri Francesco, Parigi Martina, Vignozzi LindaORCID, Baccari Maria CaterinaORCID, Ricca Valdo, Sassoli ChiaraORCID, Castellini Giovanni, Squecco Roberta
Abstract
Adiponectin (ADPN), a hormone produced by adipose tissue, facilitates gastric relaxation and can be a satiety signal in the network connecting peripheral organs and the central nervous system for feeding behavior control. Here, we performed preclinical research by morpho-functional analyses on murine gastric fundus smooth muscle to add insights into the molecular mechanisms underpinning ADPN action. Moreover, we conducted a clinical study to evaluate the potential use of ADPN as a biomarker for eating disorders (ED) based on the demonstrated gastric alterations and hormone level fluctuations that are often associated with ED. The clinical study recruited patients with ED and healthy controls who underwent blood draws for ADPN dosage and psychopathology evaluation tests. The findings of this basic research support the ADPN relaxant action, as indicated by the smooth muscle cell membrane pro-relaxant effects, with mild modifications of contractile apparatus and slight inhibitory effects on gap junctions. All of these actions engaged the ADPN/nitric oxide/guanylate cyclase pathway. The clinical data failed to unravel a correlation between ADPN levels and the considered ED, thus negating the potential use of ADPN as a valid biomarker for ED management for the moment. Nevertheless, this adipokine can modulate physiological eating behavior, and its effects deserve further investigation.
Funder
University of Florence
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference57 articles.
1. Adipokines: Deciphering the cardiovascular signature of adipose tissue;Galley;Biochem. Pharm.,2022 2. Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding;Suyama;Sci. Rep.,2016 3. Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons;Sun;Mol. Metab.,2016 4. Adiponectin at physiological level glucose-independently enhances inhibitory postsynaptic current onto NPY neurons in the hypothalamic arcuate nucleus;Suyama;Neuropeptides,2017 5. Idrizaj, E., Garella, R., Nistri, S., Dell’Accio, A., Cassioli, E., Rossi, E., Castellini, G., Ricca, V., Squecco, R., and Baccari, M.C. (2020). Adiponectin Exerts Peripheral Inhibitory Effects on the Mouse Gastric Smooth Muscle through the AMPK Pathway. Int. J. Mol. Sci., 21.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|