Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells-Reference-Cited by-同舟云学术

Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells

Published:2023-10-08 Issue:10 Volume:21 Page:529
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Cheng Ming-Ya¹,Chuang Ya-Ting²,Chang Hsueh-Wei²³⁴^ORCID,Lin Zheng-Yu¹,Chen Ching-Yeu⁵,Cheng Yuan-Bin¹⁶^ORCID

Affiliation:

1. Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan

2. Department of Biomedical Science and Environmental Biology, PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

3. Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

4. Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan

5. Department of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung 92641, Taiwan

6. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

Abstract

Five new eudensamane-type sesquiterpene lactones, clasamanes A–E (1–5), three new dolabellane-type diterpenes, clabellanes A–C (6–8), and fifteen known compounds (9–23) were isolated from the ethanolic extract of Taiwanese soft coral Clavularia spp. The structures of all undescribed components (1–8) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations. The cytotoxic activities of all isolated marine natural products were evaluated. Compound 7 showed a significant cytotoxic effect against oral cancer cell line (Ca9-22) with an IC50 value of 7.26 ± 0.17 μg/mL.

Funder

National Science and Technology Council, Taiwan

Tzu-Hui Institute of Technology

Publisher

MDPI AG

Subject

Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science

Link

https://www.mdpi.com/1660-3397/21/10/529/pdf

Reference22 articles.

1. (2019). Cancer Registry Annual Report.

2. Oral cancer: Complications of therapy;Silverman;Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol.,1999

3. Chemical studies of marine invertebrates—XXVIII: Diterpenes from Clavularia inflata (coelenterata, octocorallia, stolonifera);Braekman;Tetrahedron,1978

4. Cytotoxic dolabellane diterpenes from the Formosan soft coral Clavularia inflata;Duh;J. Nat. Prod.,2001

5. New dolabellanes from the Taiwanese soft coral Clavularia inflata;Shen;J. Chin. Chem. Soc.,2003