Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure-Reference-Cited by-同舟云学术

Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure

Published:2023-08-24 Issue:17 Volume:24 Page:13172
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Zhigacheva Irina V.¹^ORCID,Rusina Irina F.²,Krikunova Natalia I.¹,Goloschapov Aleksandr N.¹,Veprintsev Timur L.¹,Yablonskaya Olga I.¹,Trofimov Aleksei V.¹³^ORCID

Affiliation:

1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia

2. N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia

3. Moscow Institute of Physics and Technology (National Research University), Institutskii per. 9, Dolgoprudny 141701, Russia

Abstract

The increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that chemical preparations that reduce the excessive ROS generation by mitochondria should exhibit protecting properties under oxidative-stress conditions. In this context, the antioxidants resveratrol (RSV) and 2-ethyl-6-methyl-3-hydroxypyridine N-acetylcysteinate (NAC-3-HP) were examined as potential chemical protectors upon the exposure to stress, able to maintain the functional state of mitochondria.

Funder

Ministry of Science and Higher Education, Russian Federation

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/17/13172/pdf

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