Genetic Variation in miR-27a Is Associated with Fluoropyrimidine-Associated Toxicity in Patients with Dihydropyrimidine Dehydrogenase Variants after Genotype-Guided Dose Reduction
Author:
Affiliation:
1. Department of Medicine, University of Western Ontario, London, ON N6A 3K7, Canada
2. London Health Sciences Centre, London, ON N6A 5A5, Canada
3. Lawson Health Research Institute, London, ON N6C 2R5, Canada
Abstract
Funder
Ontario Institute of Cancer Research Pre-CATA
Canadian Institutes of Health Research Team Grant: Personalized Health
Wolfe Medical Research Chair in Pharmacogenomics
Publisher
MDPI AG
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Link
https://www.mdpi.com/1422-0067/24/17/13284/pdf
Reference43 articles.
1. Wigle, T.J., Tsvetkova, E.V., Welch, S.A., and Kim, R.B. (2019). Fluorouracil-Based Chemotherapy: Mini Review and Case Report. Pharmaceutics, 11.
2. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update;Amstutz;Clin. Pharmacol. Ther.,2018
3. MicroRNAs: Genomics, biogenesis, mechanism, and function;Bartel;Cell,2004
4. Komatsu, S., Kitai, H., and Suzuki, H.I. (2023). Network Regulation of microRNA Biogenesis and Target Interaction. Cells, 12.
5. MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review;Iorio;EMBO Mol. Med.,2017
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1. MIR27A Gene Polymorphism Modifies the Effect of Common DPYD Gene Variants on Severe Toxicity in Patients with Gastrointestinal Tumors Treated with Fluoropyrimidine-Based Anticancer Therapy;International Journal of Molecular Sciences;2024-08-04
2. MIR27A rs895819 TC Genotype Increases Risk of Fluoropyrimidine-Induced Severe Toxicity Independently of DPYD Variations;Pharmacogenomics;2024-01
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