1. Northumbria Healthcare Trust, North Shields NE29 8NH, UK
2. Newcastle University Medical School, Newcastle NE2 4HH, UK
3. National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London, London WC1N 1EH, UK
4. Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK