Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model
Author:
Affiliation:
1. Translational Research Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA
2. Division of Endocrinology, Columbia University, New York, NY 10032, USA
Abstract
Funder
Washington State Andy Hill CARE Fund
National Institutes of Health, National Cancer Institute
Publisher
MDPI AG
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Link
https://www.mdpi.com/1422-0067/24/17/13345/pdf
Reference54 articles.
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2. Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice;Chartoumpekis;Mol. Metab.,2015
3. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice;Chartoumpekis;JCI Insight,2018
4. NRF2 and the Moirai: Life and Death Decisions on Cell Fates;Yagishita;Antioxid. Redox Signal.,2023
5. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements;Itoh;Biochem. Biophys. Res. Commun.,1997
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