Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides-Reference-Cited by-同舟云学术

Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides

Published:2023-05-25 Issue:6 Volume:11 Page:482
ISSN:2305-6304
Container-title:Toxics
language:en
Short-container-title:Toxics

Author:

Garshin Aleksandr¹²^ORCID,Altynova Nazym¹²^ORCID,Djangalina Erika¹^ORCID,Khamdiyeva Ozada¹^ORCID,Baratzhanova Gulminyam¹²³^ORCID,Tolebaeva Anar¹,Zhaniyazov Zhasulan¹,Khussainova Elmira¹,Cakir-Kiefer Céline³^ORCID,Jurjanz Stefan³,Delannoy Matthieu³^ORCID,Djansugurova Leyla¹²^ORCID

Affiliation:

1. Institute of Genetics and Physiology, Al-Farabi Avenue, 93, Almaty 050060, Kazakhstan

2. Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Al-Farabi Avenue, 71, Almaty 050040, Kazakhstan

3. INRAE, URAFPA, Université de Lorraine, F-54000 Nancy, France

Abstract

The long-term storage of unutilized pesticides raised new problems of long-term environmental contamination. The study presents the results of surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All individuals have been surveyed concerning their consumption habits and lifestyle characteristics. An assessment of the general exposure risks of the local population was carried out using the analysis of pollutants in food products and the average levels of their consumption in the region. The cohort risk evaluation revealed that the greatest risk was associated with the regular consumption of cucumbers, pears, bell peppers, meat, and milk. The new model to estimate individual risks of long-term pesticide pollution was proposed as a calculation of the combined action of 9 risk factors, including individual genotypes, age, lifestyle, and personal pesticide consumption rates. The analysis of the predictive ability of this model showed that the final score for individual health risks corresponded to the development of chronic diseases. A high level of chromosomal aberrations was evidenced for individual genetic risk manifestations. The combined influence of all risk factors revealed contributions of 24.7% for health status and 14.2% for genetic status, while other impacts go to all unaccounted factors.

Funder

the Science Committee of the Ministry of Science and Higher Education

Publisher

MDPI AG

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology

Link

https://www.mdpi.com/2305-6304/11/6/482/pdf

Reference83 articles.

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