Revisiting Genetic Influence on Mercury Exposure and Intoxication in Humans: A Scoping Review
Author:
Crespo-Lopez Maria Elena1ORCID, Barthelemy Jean Ludger1, Lopes-Araújo Amanda1, Santos-Sacramento Leticia1ORCID, Leal-Nazaré Caio Gustavo1, Soares-Silva Isabela1, Macchi Barbarella M.2ORCID, do Nascimento José Luiz M.2, Arrifano Gabriela de Paula1, Augusto-Oliveira Marcus1ORCID
Affiliation:
1. Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, PA, Brazil 2. Laboratório de Neuroquímica Molecular e Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, PA, Brazil
Abstract
Human intoxication to mercury is a worldwide health problem. In addition to the type and length of exposure, the genetic background plays an important role in mercury poisoning. However, reviews on the genetic influence in mercury toxicity are scarce and not systematic. Therefore, this review aimed to systematically overview the most recent evidence on the genetic influence (using single nucleotide polymorphisms, SNPs) on human mercury poisoning. Three different databases (PubMed/Medline, Web of Science and Scopus) were searched, and 380 studies were found that were published from 2015 to 2022. After applying inclusion/exclusion criteria, 29 studies were selected and data on characteristics (year, country, profile of participants) and results (mercury biomarkers and quantitation, SNPs, main findings) were extracted and analyzed. The largest number of studies was performed in Brazil, mainly involving traditional populations of the Tapajós River basin. Most studies evaluated the influence of the SNPs related to genes of the glutathione system (GST, GPx, etc.), the ATP-binding cassette transporters and the metallothionein proteins. The recent findings regarding other SNPs, such as those of apolipoprotein E and brain-derived neurotrophic factor genes, are also highlighted. The importance of the exposure level is discussed considering the possible biphasic behavior of the genetic modulation phenomena that could explain some SNP associations. Overall, recommendations are provided for future studies based on the analysis obtained in this scoping review.
Funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico Fundação Amazônia de Amparo a Estudos e Pesquisas Pró-Reitoria de Pesquisa e Pós-graduação da Universidade Federal do Pará
Subject
Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology
Reference72 articles.
1. Arrifano, G.P., Augusto-Oliveira, M., Lopes-Araujo, A., Santos-Sacramento, L., Macchi, B.M., Nascimento, J., and Crespo-Lopez, M.E. (2023). Global Human Threat: The Potential Synergism between Mercury Intoxication and COVID-19. Int. J. Environ. Res. Public Health, 20. 2. Neurotoxicity and the Global Worst Pollutants: Astroglial Involvement in Arsenic, Lead, and Mercury Intoxication;Arrifano;Neurochem. Res.,2023 3. Mercury: What can we learn from the Amazon?;Macchi;Environ. Int.,2021 4. Agency for Toxic Substances and Disease Registry (2023, September 15). ATSDR 2022 Substance Priority List, Available online: https://www.atsdr.cdc.gov/spl/index.html. 5. UNEP (2019). Global Mercury Assessment 2018, United Nations Environment Programme.
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