Abstract
The use of γ-aminobutyric acid (GABA) as a starting material in a multicomponent reaction has resulted in the preparation of the zwitterionic 1,3-bis(3-carboxypropyl)imidazole (bcpim). The synthesis of this imidazole derivative in a one-pot procedure with stoichiometric amounts of the corresponding reagents (formaldehyde, glyoxal, and GABA in a 1:1:2 ratio) has resulted in a straightforward and effective methodology, meaning a significant improvement from a sustainable point of view.
Funder
Ministerio de Ciencia, Innovación y Universidades
Ministerio de Ciencia e Innovación
Generalitat Valenciana
University of Alicante
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Cited by
2 articles.
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