Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment

Author:

Wang Kehao12ORCID,Qiu Ziyan13,Xie Yiping45ORCID,Cai Shuo3,Zhao Yang12,Pierscionek Barbara K.6ORCID,Guo Jiangzhen12ORCID,Fan Yubo123

Affiliation:

1. Key Laboratory for Biomechanics and Mechanobiology of Ministry for Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China

2. School of Engineering Medicine, Beihang University, Beijing 100191, China

3. School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China

4. School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100043, China

5. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China

6. Faculty of Health, Education, Medicine and Social Care, Medical Technology Research Centre, Anglia Ruskin University, Bishops Hall Lane, Chelmsford, CM1 1SQ, UK

Abstract

The young eye has an accommodative ability involving lens shape changes to focus over different distances. This function gradually decreases with age, resulting in presbyopia. Greater insights into the mechanical properties of anterior eye structures can improve understanding of the causes of presbyopia. The present study aims to develop a multi-axis stretching device for evaluating the mechanical properties of the intact eye lens. A stretching device integrating the mechanical stretcher, motor, torque sensor and data transmission mechanism was designed and developed by 3D printing. The mechanical stretcher can convert rotation into radial movement, both at constant speeds, according to the spiral of Archimedes. The loading unit equipped with eight jaws can hold the eye sample tightly. The developed device was validated with a spring of known constant and was further tested with anterior porcine eye segments. The validation experiment using the spring resulted in stiffness values close to the theoretical spring constant. Findings from measurements with porcine eye samples indicated that the measured forces are within the ranges reported in the literature. The developed multi-axis stretching device has good repeatability during experiments with similar settings and can be reliably used for mechanical evaluations of the intact eye lens.

Funder

National Natural Science Foundation of China

Central Universities and the Higher Education Discipline Innovation Project

Publisher

MDPI AG

Subject

Bioengineering

Reference50 articles.

1. The gradient index lens of the eye: An opto-biological synchrony;Pierscionek;Prog. Retin. Eye Res.,2012

2. Biomechanics of the human lens and accommodative system: Functional relevance to physiological states;Wang;Prog. Retin. Eye Res.,2019

3. Bron, A.J., Tripathi, R.C., and Tripathi, B.J. (1997). Wolf ’s Anatomy of the Eye and Orbit, Hodder Education Publishers. [8th ed.].

4. Physiology of Accommodation and Presbyopia;Werner;Arq. Bras. Oftalmol.,2000

5. The eye in focus: Accommodation and presbyopia;Charman;Clin. Exp. Optom.,2008

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