An In Vivo Rat Study of Bioresorbable Mg-2Zn-2Ga Alloy Implants-Reference-Cited by-同舟云学术

An In Vivo Rat Study of Bioresorbable Mg-2Zn-2Ga Alloy Implants

Published:2023-02-20 Issue:2 Volume:10 Page:273
ISSN:2306-5354
Container-title:Bioengineering
language:en
Short-container-title:Bioengineering

Author:

Drobyshev Alexey¹,Gurganchova Zaira¹^ORCID,Redko Nikolay¹^ORCID,Komissarov Alexander¹²^ORCID,Bazhenov Viacheslav³^ORCID,Statnik Eugene S.⁴^ORCID,Sadykova Iuliia A.⁴,Sviridov Eugeny¹,Salimon Alexey I.⁴^ORCID,Korsunsky Alexander M.⁴⁵^ORCID,Zayratyants Oleg⁶,Ushmarov Denis⁷,Yanushevich Oleg¹

Affiliation:

1. Laboratory of Medical Bioresorption and Bioresistance, Moscow State University of Medicine and Dentistry, 127473 Moscow, Russia

2. Laboratory of Hybrid Nanostructured Materials, National University of Science and Technology “MISiS”, 119049 Moscow, Russia

3. Casting Department, National University of Science and Technology “MISiS”, 119049 Moscow, Russia

4. HSM Laboratory, Center for Digital Engineering, Skoltech, 121205 Moscow, Russia

5. Trinity College, Oxford OX1 3BH, UK

6. Laboratory of the Clinical Medical Center, Moscow State University of Medicine and Dentistry, 111398 Moscow, Russia

7. Educational and Production Department, Kuban State Medical University, 350912 Krasnodar, Russia

Abstract

In the present study, pins made from the novel Mg-2Zn-2Ga alloy were installed within the femoral bones of six Wistar rats. The level of bioresorption was assessed after 1, 3, and 6 months by radiography, histology, SEM, and EDX. Significant bioresorption was evident after 3 months, and complete dissolution of the pins occurred at 6 months after the installation. No pronounced gas cavities could be found at the pin installation sites throughout the postoperative period. The animals’ blood parameters showed no signs of inflammation or toxication. These findings are sufficiently encouraging to motivate further research to broaden the experimental coverage to increase the number of observed animals and to conduct tests involving other, larger animals.

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

MDPI AG

Subject

Bioengineering

Link

https://www.mdpi.com/2306-5354/10/2/273/pdf

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