Abstract
Background Rosai-Dorfman disease (RDD), the massive lymphadenopathy characterized by the proliferation of sinus histiocytosis, is a relatively idiopathic benign disease with unknown etiology. We reported a rare case of thymic RDD detected by 18F-FDG PET/CT. A 23-year-old man with right-sided chest pain underwent 18F-FDG PET/CT scan, showing increased 18F-FDG uptake in an anterior mediastinal mass corresponding to a thymic lesion at an enhanced CT scan. The patient was referred to surgery with the clinical suspicion of thymic malignancy. The histological examination and immunohistochemical results confirmed RDD. Conclusions This was the first case report of RDD isolated to the thymus and initially presented with chest pain. Moreover, there was no characteristic painless neck lymphadenopathy at any stage of the disease course. Thus, for young patients with thymus mass, RDD should be considered a rare but possible diagnosis.
Funder
National Natural Science Foundation of China
Medical Youth Talent Project of Jiangsu Province
Gusu Health Talent Program
Suzhou People’s Livelihood Science and Technology Project
Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University
Open Foundation of Nuclear Medicine Laboratory of Mianyang Central Hospital
Subject
Radiology, Nuclear Medicine and imaging
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