Adiposity Reduction by Cucumis melo var. gaettongchamoe Extract in High-Fat Diet-Induced Obese Mice

Author:

Park Sun Young1ORCID,Kim Ji Eun2,Kang He Mi3ORCID,Song Hee Jin2,Kang Nam Jun4,Hwang Dae Youn2ORCID,Choi Young-Whan3

Affiliation:

1. Bio-IT Fusion Technology Research Institute, Pusan National University, Busan 46241, Republic of Korea

2. Department of Biomaterials Science, Pusan National University, Miryang 50463, Republic of Korea

3. Department of Horticultural Bioscience, Pusan National University, Miryang 50463, Republic of Korea

4. Department of Horticulture, Gyeongsang National University, Jinju 52828, Republic of Korea

Abstract

This study investigated the anti-obesity effects of Cucumis melo var. gaettongchamoe (CG) in mice fed a high-fat diet (HFD). The mice received CG water extract (CGWE) treatment for 8 weeks, and changes in body weight and serum lipid levels were analyzed. The HFD + vehicle group showed a significant increase in body weight compared to the control group, while the HFD + CGWE and HFD + positive (orlistat) groups exhibited reduced body weight. Lipid profile analysis revealed lower levels of total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein cholesterol in the HFD + CGWE group compared to the HFD + vehicle group. The HFD + vehicle group had increased abdominal fat weight and fat content, whereas both HFD + CGWE groups showed significant reductions in abdominal fat content and adipocyte size. Additionally, CGWE administration downregulated mRNA expression of key proteins involved in neutral lipid metabolism. CGWE also promoted hepatic lipolysis, reducing lipid droplet accumulation in hepatic tissue and altering neutral lipid metabolism protein expression. Furthermore, CGWE treatment reduced inflammatory mediators and suppressed the activation of the mitogen-activated protein kinase pathway in hepatic tissue. In conclusion, CGWE shows promise as a therapeutic intervention for obesity and associated metabolic dysregulation, including alterations in body weight, serum lipid profiles, adipose tissue accumulation, hepatic lipolysis, and the inflammatory response. CGWE may serve as a potential natural anti-obesity agent.

Funder

Korean government

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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