Abstract
The enzyme-catalyzed monoacetylation of prochiral bis (2-hydroxymethylphenyl)methylphosphine and bis (2-hydroxymethylphenyl)phenylphosphine and their P-sulfides gave, in one single step, as a result of desymmetrisation, the corresponding monoacetates in moderate yields and with an enantiomeric excess of 16 to 98%, depending on the substrate structure and enzyme applied. The absolute configurations of the selected products were determined by a chemical correlation. This led to the conclusion that, in the case of phosphines, phosphine oxides and phosphine sulfides enzymes preferentially produce compounds of the same spatial arrangement. The new compounds obtained will be transformed into chiral catalysts/ligands.
Funder
National Research Centre (NCN), Poland
Subject
Physical and Theoretical Chemistry,Catalysis
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献