Affiliation:
1. Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, China
Abstract
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. Over 80 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antidiabetic, cardiovascular, and other activities, were reviewed. A review of recent studies on the use of isoxazoles and isoxazolines moiety derivative activities for natural products is presented here, focusing on the parameters that affect the bioactivity of these compounds.
Funder
National Natural Science Foundation of China
Open Project of Stake Key Laboratory of Natural and Biomimetic Drugs, Peking University
Open Project of Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education
Youth Innovative Talent Cultivation Projects of Shihezi University
Open Sharing Fund for the Large-scale Instruments and Equipments of Shihezi University
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Cited by
8 articles.
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