Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer
-
Published:2024-01-26
Issue:3
Volume:25
Page:1561
-
ISSN:1422-0067
-
Container-title:International Journal of Molecular Sciences
-
language:en
-
Short-container-title:IJMS
Author:
Yang Xueni1, Xiong Shizheng1ORCID, Zhao Xinmiao1, Jin Jiaming1, Yang Xinbing2, Du Yajing2, Zhao Linjie1, He Zhiheng1, Gong Chengjun1, Guo Li1, Liang Tingming2ORCID
Affiliation:
1. State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China 2. Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing 210023, China
Abstract
Autophagy, a complex and highly regulated cellular process, is critical for the maintenance of cellular homeostasis by lysosomal degradation of cellular debris, intracellular pathogens, and dysfunctional organelles. It has become an interesting and attractive topic in cancer because of its dual role as a tumor suppressor and cell survival mechanism. As a highly conserved pathway, autophagy is strictly regulated by diverse non-coding RNAs (ncRNAs), ranging from short and flexible miRNAs to lncRNAs and even circRNAs, which largely contribute to autophagy regulatory networks via complex RNA interactions. The potential roles of RNA interactions during autophagy, especially in cancer procession and further anticancer treatment, will aid our understanding of related RNAs in autophagy in tumorigenesis and cancer treatment. Herein, we mainly summarized autophagy-related mRNAs and ncRNAs, also providing RNA–RNA interactions and their potential roles in cancer prognosis, which may deepen our understanding of the relationships between various RNAs during autophagy and provide new insights into autophagy-related therapeutic strategies in personalized medicine.
Funder
National Natural Science Foundation of China key project of social development in Jiangsu Province key projects of Natural Science Research in Universities of Jiangsu Province Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University Shandong Provincial Key Laboratory of Biophysics Priority Academic Program Development of Jiangsu Higher Education Institution
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference125 articles.
1. Targeting autophagy as a therapeutic strategy against pancreatic cancer;Yamamoto;J. Gastroenterol.,2022 2. Chen, Y., Zhang, X., Yang, H., Liang, T., and Bai, X. (2023). The “Self-eating” of cancer-associated fibroblast: A potential target for cancer. Biomed. Pharmacother., 163. 3. The role for autophagy in cancer;White;J. Clin. Investig.,2015 4. Autophagy, Metabolism, and Cancer;White;Clin. Cancer Res.,2015 5. Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species;Manent;Oncogene,2017
|
|