Affiliation:
1. Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszow, 4 Zelwerowicza Street, 35-601 Rzeszow, Poland
Abstract
Nitroxides are stable free radicals that have antioxidant properties. They react with many types of radicals, including alkyl and peroxyl radicals. They act as mimics of superoxide dismutase and stimulate the catalase activity of hemoproteins. In some situations, they may exhibit pro-oxidant activity, mainly due to the formation of oxoammonium cations as products of their oxidation. In this review, the cellular effects of nitroxides and their effects in animal experiments and clinical trials are discussed, including the beneficial effects in various pathological situations involving oxidative stress, protective effects against UV and ionizing radiation, and prolongation of the life span of cancer-prone mice. Nitroxides were used as active components of various types of nanoparticles. The application of these nanoparticles in cellular and animal experiments is also discussed.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference207 articles.
1. Selective targeting of synthetic antioxidants to mitochondria: Towards a mitochondrial medicine for neurodegenerative diseases?;Dessolin;Eur. J. Pharmacol.,2002
2. A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria;Trnka;Free Radic. Biol. Med.,2008
3. Zhdanov, R., Sukhanov, V., and Shvets, V. (1992). Bioactive Spin Labels, Springer.
4. Comparative 5-doxylstearoyllecithin and 3-doxylcholestane EPR spin labeling study of phospholipid bilayer perturbation by different oxidized lecithin species;Megli;Biochim. Biophys. Acta BBA Biomembr.,2010
5. Electron-transfer reactions. Oxidation of Grignard reagents in the presence of an aminoxyl as a radical-trapping agent;Carloni;J. Org. Chem.,1991