Affiliation:
1. Cardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland
2. Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, 02-091 Warsaw, Poland
Abstract
Coronary artery disease (CAD) in women occurs later than in men. Underlying atherosclerosis, a chronic process of lipoprotein deposition in arterial walls with a prominent inflammatory component, is influenced by several risk factors. In women, commonly used inflammatory markers are generally found to be related to the occurrence of acute coronary syndrome (ACS), as well as the development of other diseases that influence CAD. New inflammatory markers derived from total blood count—systemic inflammatory response index (SII), systemic inflammatory reaction index (SIRI), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR)—were analyzed in the group of 244 elderly, postmenopausal women with the diagnosis of ACS or stable CAD. SII, SIRI, MLR, and NLR were significantly higher in women with ACS compared to those with stable CAD (p < 0.05 for all)—the highest values were observed in women with NSTEMI. MLR from new inflammatory markers, HDL, and history of MI turned out to be significant factors associated with ACS. These results suggest that MLR as representative of blood count-derived inflammatory markers may be considered as additional CVD risk factors in women with suspected ACS.
Funder
Medical University of Warsaw
Reference80 articles.
1. European Society of Cardiology: Cardiovascular Disease Statistics 2019;Timmis;Eur. Heart J.,2020
2. Sex differences in mechanisms, presentation and management of ischaemic heart disease;Crea;Atherosclerosis,2015
3. Aryan, L., Younessi, D., Zargari, M., Banerjee, S., Agopian, J., Rahman, S., Borna, R., Ruffenach, G., Umar, S., and Eghbali, M. (2020). The Role of Estrogen Receptors in Cardiovascular Disease. Int. J. Mol. Sci., 21.
4. Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: A report from the NHLBI-sponsored WISE study;Johnson;J. Am. Coll. Cardiol.,2003
5. Endogenous Sex Hormones and Incident Cardiovascular Disease in Post-Menopausal Women;Zhao;J. Am. Coll. Cardiol.,2018
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