Anti-Aging Potential of a Novel Ingredient Derived from Sugarcane Straw Extract (SSE)
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Published:2023-12-19
Issue:1
Volume:25
Page:21
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Carvalho Maria João1, Pedrosa Sílvia Santos1ORCID, Mendes Adélia12ORCID, Azevedo-Silva João1ORCID, Fernandes João12, Pintado Manuela1ORCID, Oliveira Ana L. S.1ORCID, Madureira Ana Raquel1
Affiliation:
1. CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal 2. Amyris Bio Products Portugal, Unipessoal Lda., Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
Abstract
Natural and sustainable anti-aging ingredients have gained attention from the cosmetic industry. This study evaluated the anti-aging potential of a sugarcane straw extract-based (SSE) cosmetic ingredient. First, cytotoxicity tests were assessed in keratinocytes and fibroblast cell lines, and sensitization was carried out through the direct peptide reactivity assay. Subsequently, various anti-aging properties were investigated, including inhibiting skin aging-related enzymes, promoting elastin and hyaluronic acid synthesis, and anti-pollution activity. Finally, a permeability assay using a synthetic membrane resembling skin was conducted. The results demonstrated that the SSE ingredient effectively inhibited elastase (55%), collagenase (25%), and tyrosinase (47%) while promoting hyaluronic acid production at non-cytotoxic and low-sensitizer concentrations. Moreover, it reduced the inflammatory response provoked by urban pollution, as evidenced by decreased levels of IL1-α and IL-6. However, it was observed that the phenolic compounds predominantly reached the skin’s surface, indicating a limited ability to penetrate deeper layers of the skin. Therefore, it can be concluded that the SSE ingredient holds anti-aging properties, albeit with limited penetration into deeper skin layers. Further research and formulation advancements are needed to optimize the ingredient’s ability to reach and exert its effects in deeper skin layers.
Funder
Amyris Bio Products Portugal Unipessoal Lda and Escola Superior de Biotecnologia
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
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