Immunotherapy for Metastatic Non-Small Cell Lung Cancer: Therapeutic Advances and Biomarkers

Author:

Russano Marco1,La Cava Giulia1,Cortellini Alessio1,Citarella Fabrizio1,Galletti Alessandro2ORCID,Di Fazio Giuseppina Rita1,Santo Valentina1,Brunetti Leonardo1,Vendittelli Alessia1,Fioroni Iacopo1,Pantano Francesco1,Tonini Giuseppe1,Vincenzi Bruno1

Affiliation:

1. Department of Medical Oncology, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 21, 00128 Rome, Italy

2. Division of Medical Oncology, San Camillo Forlanini Hospital, 00152 Roma, Italy

Abstract

Immunotherapy has revolutionized the treatment paradigm of non-small cell lung cancer and improved patients’ prognosis. Immune checkpoint inhibitors have quickly become standard frontline treatment for metastatic non-oncogene addicted disease, either as a single agent or in combination strategies. However, only a few patients have long-term benefits, and most of them do not respond or develop progressive disease during treatment. Thus, the identification of reliable predictive and prognostic biomarkers remains crucial for patient selection and guiding therapeutic choices. In this review, we provide an overview of the current strategies, highlighting the main clinical challenges and novel potential biomarkers.

Publisher

MDPI AG

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