A Rare Case of Complete-Immunotherapy-Responsive Metastatic Non-Small Cell Lung Cancer with Long Lasting Progression-Free Survival: A Case Report-Reference-Cited by-全球学者库

A Rare Case of Complete-Immunotherapy-Responsive Metastatic Non-Small Cell Lung Cancer with Long Lasting Progression-Free Survival: A Case Report

Published:2024-01-26 Issue:2 Volume:31 Page:723-732
ISSN:1718-7729
Container-title:Current Oncology
language:en
Short-container-title:Current Oncology

Author:

De Intinis Claudia¹^ORCID,Izzo Paolo¹^ORCID,Codacci-Pisanelli Massimo¹,Izzo Luciano¹^ORCID,Messineo Daniela²^ORCID,Sibio Simone¹^ORCID,Campagnol Monica¹,Lai Silvia³^ORCID,Molle Marcello⁴^ORCID,Izzo Sara⁴

Affiliation:

1. Department of Surgery “Pietro Valdoni”, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy

2. Department of Radiological Sciences, Oncology and Anatomo-Pathological Science, “Sapienza” University of Rome, Viale dell’Universitá 31/33, 00161 Rome, Italy

3. Department of Translational and Precision Medicine, Nephrology Unit, “Sapienza” University of Rome, Viale dell’Universitá 31/33, 00161 Rome, Italy

4. Multidisciplinary Department of Medical-Surgical and Dental Specialties, Plastic Surgery Unit, Università degli Studi della Campania “Luigi Vanvitelli”, Piazza Luigi Miraglia 1, 80138 Naples, Italy

Abstract

Background and introduction: Lung cancer is a prevalent and deadly disease globally. Non-small cell lung cancer (NSCLC) is the most common subtype, comprising 85% of cases. Case report: A 65-year-old male ex-smoker presented to our facility with a nocturnal cough. Various investigations revealed that he had metastatic NSCLC, for which he underwent chemotherapy with cisplatin and gemcitabine, followed by immunotherapy with Nivolumab. He achieved a complete response to the therapy and has remained free from recurrence for over 7 years since the initial diagnosis. Discussion and Conclusions: The treatment of metastatic NSCLC remains a significant therapeutic challenge, but the implementation of new therapeutic techniques has expanded the possibilities of achieving complete and durable eradication of the disease.

Publisher

MDPI AG

Link

https://www.mdpi.com/1718-7729/31/2/53/pdf

Reference36 articles.

1. World Health Organization (2023, June 06). Lung Cancer. Available online: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.

2. Lung Cancer 2020: Epidemiology, Etiology, and Prevention;Bade;Clin. Chest Med.,2020

3. Office of the Surgeon General, U.S. (1972). Public Health Service. The Health Consequences of Smoking, 72-7516 PNH; National Clearinghouse for Smoking Health.

4. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Bray;CA Cancer J. Clin.,2018

5. Quantitative Health Risk Assessment of Indoor Radon: A Systematic Review;Ajrouche;Radiat. Prot. Dosim.,2017