12-Month Trajectories of Health-Related Quality of Life Following Hospitalization in German Cancer Centers—A Secondary Data Analysis

Author:

Eichler Martin1ORCID,Hönig Klaus2,Bergelt Corinna3,Faller Hermann4,Maatouk Imad56ORCID,Hornemann Beate1,Stein Barbara7ORCID,Teufel Martin8,Goerling Ute9,Erim Yesim10,Geiser Franziska11,Niecke Alexander12,Senf Bianca1314,Weis Joachim15ORCID

Affiliation:

1. Medical Faculty, National Center for Tumor Diseases (NCT/UCC), Technical University Dresden, 01307 Dresden, Germany

2. Department of Psychosomatic Medicine and Psychotherapy, Comprehensive Cancer Center Ulm (CCCU), Ulm University Hospital, 89070 Ulm, Germany

3. Hamburg Hubertus Wald—University Cancer Center (CCC), University Clinic Centre, 20251 Hamburg, Germany

4. Department Medical Psychology and Psychotherapy, Comprehensive Cancer Center Mainfranken, University of Würzburg, 97080 Würzburg, Germany

5. Department Internal Medicine and Psychosomatics, University Clinic Centre Heidelberg, 69120 Heidelberg, Germany

6. Section of Psychosomatic Medicine, Psychotherapy and Psychooncology, Department of Internal Medicine II, Julius-Maximilian University Würzburg, 97080 Würzburg, Germany

7. Department of Psychosomatic Medicine and Psychotherapy, General Hospital Nuremberg, Paracelsus Medical University, 90419 Nuremberg, Germany

8. Department Psychosomatic Medicine and Psychotherapy, Comprehensive Cancer Center Essen (WTZ) and LVR University Hospital, University of Duisburg-Essen, 45122 Essen, Germany

9. Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität and Berlin Institute of Health, 10117 Berlin, Germany

10. Department Psychosomatic Medicine, University Clinic Centre Erlangen, 91054 Erlangen, Germany

11. Department Psychosomatic Medicine, University Clinic Centre Bonn, 53127 Bonn, Germany

12. Faculty of Medicine & University Hospital, Department Psychosomatics and Psychotherapy, University of Cologne, 50937 Köln, Germany

13. University Cancer Center, University Clinic Centre Frankfurt, 60590 Frankfurt, Germany

14. Protestant College of Darmstadt, University of Applied Sciences, 64293 Darmstadt, Germany

15. Faculty of Medicine and Medical Center University of Freiburg, Department Self-Help Research, Comprehensive Cancer Center, 79106 Freiburg, Germany

Abstract

Patient-reported outcomes (PROs) offer a diverse array of potential applications within medical research and clinical practice. In comparative research, they can serve as tools for delineating the trajectories of health-related quality of life (HRQoL) across various cancer types. We undertook a secondary data analysis of a cohort of 1498 hospitalized cancer patients from 13 German cancer centers. We assessed the Physical and Mental Component Scores (PCS and MCS) of the 12-Item Short-Form Health Survey at baseline (t0), 6 (t1), and 12 months (t2), using multivariable generalized linear regression models. At baseline, the mean PCS and MCS values for all cancer patients were 37.1 and 44.3 points, respectively. We observed a significant improvement in PCS at t2 and in MCS at t1. The most substantial and significant improvements were noted among patients with gynecological cancers. We found a number of significant differences between cancer types at baseline, t1, and t2, with skin cancer patients performing best across all time points and lung cancer patients performing the worst. MCS trajectories showed less pronounced changes and differences between cancer types. Comparative analyses of HRQoL scores across different cancer types may serve as a valuable tool for enhancing health literacy, both among the general public and among cancer patients themselves.

Funder

German Cancer Aid

Publisher

MDPI AG

Reference35 articles.

1. U.S. Department of Health and Human Services FDA Center for Drug Evaluation and Research, U.S. Department of Health and Human Services FDA Center for Biologics Evaluation and Research, and U.S. Department of Health and Human Services FDA Center for Devices and Radiological Health Guidance for Industry (2006). Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims: Draft Guidance. Health Qual. Life Outcomes, 4, 79.

2. The Use of the Eortc Item Library to Supplement Eortc Quality of Life Instruments;Kulis;Value Health,2017

3. Development of a Functional Assessment of Chronic Illness Therapy Item Library and Primary Symptom List for the Assessment of Patient-Reported Adverse Events Associated with Immune Checkpoint Modulators;Webster;J. Cancer Metastasis Treat.,2020

4. Quality of Life in Cancer Patients-a Comparison of Inpatient, Outpatient, and Rehabilitation Settings;Hinz;Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer,2018

5. Using Patient-Reported Outcomes to Compare Relative Burden of Cancer: EQ-5D and Functional Assessment of Cancer Therapy-General in Eleven Types of Cancer;Pickard;Clin. Ther.,2016

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3