The Signaling Mechanism of Remote Postconditioning of the Heart: Prospects of the Use of Remote Postconditioning for the Treatment of Acute Myocardial Infarction

Author:

Ryabov Vyacheslav V.1ORCID,Vyshlov Evgenii V.1,Maslov Leonid N.1ORCID,Mukhomedzyanov Alexandr V.1ORCID,Naryzhnaya Natalia V.1ORCID,Boshchenko Alla A.1,Gombozhapova Aleksandra E.1ORCID,Samoylova Julia O.1ORCID

Affiliation:

1. Cardiology Research Institute, Tomsk National Research Medical Center of the RAS, 634012 Tomsk, Russia

Abstract

Acute myocardial infarction (AMI) remains the leading cause of mortality in the world, highlighting an urgent need for the development of novel, more effective approaches for the treatment of AMI. Remote postconditioning (RPost) of the heart could be a useful approach. It was demonstrated that RPost triggers infarct size reduction, improves contractile function of the heart in reperfusion, mitigates apoptosis, and stimulates autophagy in animals with coronary artery occlusion and reperfusion. Endogenous opioid peptides and adenosine could be involved in RPost. It was found that kinases and NO-synthase participate in RPost. KATP channels, MPT pore, and STAT3 could be hypothetical end-effectors of RPost. Metabolic syndrome and old age abolish the cardioprotective effect of RPost in rats. The data on the efficacy of RPost in clinical practice are inconsistent. These data are discussed in the review.

Publisher

MDPI AG

Subject

General Medicine

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