Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?-Reference-Cited by-同舟云学术

Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?

Published:2023-05-26 Issue:11 Volume:12 Page:1481
ISSN:2073-4409
Container-title:Cells
language:en
Short-container-title:Cells

Author:

Pisani Laura Francesca¹²^ORCID,Teani Isabella³,Vecchi Maurizio⁴⁵,Pastorelli Luca⁶⁷

Affiliation:

1. Gastroenterology and Endoscopy Unit, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy

2. Immunology and Functional Genomics Unit, Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy

3. Department of Medicine, University of Verona, 37129 Verona, Italy

4. Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy

5. Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy

6. Department of Health Sciences, University of Milan, 20122 Milan, Italy

7. Gastroenterology and Liver Unit, ASST Santi Paolo e Carlo, 20142 Milan, Italy

Abstract

Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. IL-33 is a novel contributing factor in tumorigenesis and plays a critical role in regulating angiogenesis and cancer progression in a variety of human cancers. The partially unraveled role of IL-33/ST2 signaling in gastrointestinal tract cancers is being investigated through the analysis of patients’ samples and by studies in murine and rat models. In this review, we discuss the basic biology and mechanisms of release of the IL-33 protein and its involvement in gastrointestinal cancer onset and progression.

Funder

Research Grant ‘LETIZIA CASTELLI SCHUBERT’

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2073-4409/12/11/1481/pdf

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