A Microenvironment-Related Nine-Gene Signature May Predict Survival in Mycosis Fungoides Patients at Diagnosis

Author:

Alberti-Violetti Silvia12ORCID,Sapienza Maria Rosaria3ORCID,Del Corvo Marcello3,Melle Federica3ORCID,Motta Giovanna3,Venegoni Luigia2ORCID,Cerroni Lorenzo4,Cota Carlo5,Pileri Alessandro67ORCID,Berti Emilio1,Pileri Stefano A.3ORCID

Affiliation:

1. Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy

2. Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy

3. Division of Diagnostic Haematopathology, European Institute of Oncology IRCCS, 20139 Milan, Italy

4. Research Unit of Dermatopathology, Medical University of Graz, 8036 Graz, Austria

5. Dermatopathology Laboratory San Gallicano, Dermatological Institute IRCCS, 00144 Rome, Italy

6. Dermatology Unit, IRCCS AUBO, 40138 Bologna, Italy

7. Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy

Abstract

Mycosis fungoides (MF) is the most common cutaneous lymphoma characterized by an indolent course. Prognosis is stage-based but this approach does not reflect the different outcomes within stages. Considering that tumor microenvironment is known to be involved in MF pathogenesis and progression, we decided to investigate 99 MF cases by using the PanCancer Immune Profiling Panel. We identified and validated a signature of 9 genes able to predict MF survival and distinguish a high-risk group with a worse outcome from a low-risk group of cases with a better outcome. At the molecular level, low-risk vs. high-risk cases reported a global upregulation of immune genes, enriched in cytokines, and a higher density of dendritic cells and mast cells, possibly associated with a more favorable clinical course.

Funder

Associazione Italiana Ricerca sul Cancro

Publisher

MDPI AG

Subject

General Medicine

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