The Effects of Lithium on Proprioceptive Sensory Function and Nerve Conduction

Author:

Brock Kaitlyn E.1,Elliott Elizabeth R.1ORCID,Taul Alaina C.1,Asadipooya Artin1,Bocook Devin1,Burnette Tessa1,Chauhan Isha V.1,Chhadh Bilal1,Crane Ryan1,Glover Ashley1,Griffith Joshua1,Hudson JayLa A.1,Kashif Hassan1,Nwadialo Samuel O.1,Neely Devan M.1,Nukic Adel1,Patel Deep R.1,Ruschman Gretchen L.1,Sales Johnathan C.1,Yarbrough Terra1,Cooper Robin L.1ORCID

Affiliation:

1. Department of Biology, University of Kentucky, Lexington, KY 40506-0225, USA

Abstract

Animals are exposed to lithium (Li+) in the natural environment as well as by contact with industrial sources and therapeutic treatments. Low levels of exposure over time and high volumes of acute levels can be harmful and even toxic. The following study examines the effect of high-volume acute levels of Li+ on sensory nerve function and nerve conduction. A proprioceptive nerve in the limbs of a marine crab (Callinectes sapidus) was used as a model to address the effects on stretch-activated channels (SACs) and evoked nerve conduction. The substitution of Li+ for Na+ in the bathing saline slowed nerve conduction rapidly; however, several minutes were required before the SACs in sensory endings were affected. The evoked compound action potential slowed in conduction and slightly decreased in amplitude, while the frequency of nerve activity with joint movement and chordotonal organ stretching significantly decreased. Both altered responses could be partially restored with the return of a Na+-containing saline. Long-term exposure to Li+ may alter the function of SACs in organisms related to proprioception and nerve conduction, but it remains to be investigated.

Funder

Beckman Scholarship

College of Arts and Sciences Summer Research Fellowship

Department of Biology, University of Kentucky

Personal funds

Publisher

MDPI AG

Subject

General Energy

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