Affiliation:
1. Frontiers Science Center for New Organic Matter, the State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
2. Tianjin Baogang Rare Earth Research Institute Co., Ltd., Tianjin 300301, China
Abstract
Metal carbenes are widely acknowledged as a category of highly effective intermediates that facilitate otherwise inaccessible transformations. In recent decades, carbene chemistry has made considerable advances and has demonstrated remarkable abilities in the formation of diverse chemical bonds and the synthesis of structurally distinctive molecules. Nevertheless, the majority of research within this field has concentrated on α-carbon-substituted carbenes, with comparatively little investigation of carbenes that have been functionalized with a wider structural variety, particularly those that have been substituted with heteroatoms (e.g., O, N, P, S, Si, Ge, Sn and B). The objective of this review is to elucidate the advancements in enantioselective transfer reactions involving metal carbenes substituted with these elements, thereby highlighting their contribution to the expansion of the structural diversity and synthetic utility of carbenes in contemporary chemistry.
Funder
the National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Research Funds from China Northern Rare Earth (Group) High-tech Co., Ltd.
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