Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review

Author:

Tan Swee Ching,Bhattamisra Subrat Kumar,Chellappan Dinesh KumarORCID,Candasamy Mayuren

Abstract

Centella asiatica is a popular herb well-known for its wide range of therapeutic effects and its use as a folk medicine for many years. Its therapeutic properties have been well correlated with the presence of asiaticoside, madecassoside, asiatic and madecassic acids, the pentacyclic triterpenes. The herb has been extensively known to treat skin conditions; nevertheless, several pre-clinical and clinical studies have scientifically demonstrated its effectiveness in other disorders. Among the active constituents that have been identified in Centella asiatica, madecassoside has been the subject of only a relatively small number of scientific reports. Therefore, this review, while including other major constituents of this plant, focuses on the therapeutic potential, pharmacokinetics and toxicity of madecassoside.

Funder

Fundamental Research Grant Scheme (FRGS) of the Ministry of Higher Education, Malaysia

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

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