Electrostatic and Covalent Binding of an Antibacterial Polymer to Hydroxyapatite for Protection against Escherichia coli Colonization

Author:

Chakraborty Sudip1,Katsifis Georgio2,Roohani Iman134,Boyer Cyrille5,McKenzie David23,Willcox Mark D. P.6ORCID,Chen Renxun1ORCID,Kumar Naresh1ORCID

Affiliation:

1. School of Chemistry, UNSW Sydney, Sydney, NSW 2052, Australia

2. School of Physics, University of Sydney, Sydney, NSW 2006, Australia

3. Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia

4. School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia

5. School of Chemical Engineering, UNSW Sydney, Sydney, NSW 2052, Australia

6. School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW 2052, Australia

Abstract

Orthopedic-device-related infections are notorious for causing physical and psychological trauma to patients suffering from them. Traditional methods of treating these infections have relied heavily on antibiotics and are becoming ineffectual due to the rise of antibiotic-resistant bacteria. Mimics of antimicrobial peptides have emerged as exciting alternatives due to their favorable antibacterial properties and lack of propensity for generating resistant bacteria. In this study, the efficacy of an antibacterial polymer as a coating material for hydroxyapatite and glass surfaces, two materials with wide ranging application in orthopedics and the biomedical sciences, is demonstrated. Both physical and covalent modes of attachment of the polymer to these materials were explored. Polymer attachment to the material surfaces was confirmed via X-ray photoelectron spectroscopy and contact angle measurements. The modified surfaces exhibited significant antibacterial activity against the Gram-negative bacterium E. coli, and the activity was retained for a prolonged period on the surfaces of the covalently modified materials.

Funder

NHMRC

Publisher

MDPI AG

Subject

General Materials Science

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