Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration-Reference-Cited by-同舟云学术

Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration

Published:2024-06-22 Issue:13 Volume:12 Page:1937
ISSN:2227-7390
Container-title:Mathematics
language:en
Short-container-title:Mathematics

Author:

Andreucci Daniele¹^ORCID,Bersani Alberto M.²^ORCID,Bersani Enrico³,Caressa Paolo³^ORCID,Dumett Miguel⁴^ORCID,Leon Trujillo Francisco James⁵^ORCID,Marconi Silvia³^ORCID,Rubio Obidio⁶^ORCID,Zarate-Pedrera Yessica E.⁷^ORCID

Affiliation:

1. Department of Basic and Applied Sciences for Engineering, Sapienza University, 00185 Rome, Italy

2. Department of Mechanical and Aerospace Engineering, Sapienza University, 00185 Rome, Italy

3. International Research Center on Mathematics and Mechanics of Complex Systems (M&MOCS), 67100 L’Aquila, Italy

4. Computational Science Research Center, San Diego State University, San Diego, CA 92182, USA

5. Instituto de Investigación Científica, Universidad de Lima, Santiago de Surco 15023, Peru

6. Instituto de Investigación en Matemática, Departamento de Matemáticas, Universidad Nacional de Trujillo, Trujillo 13011, Peru

7. Departamento de Matemáticas, Universidad Nacional de Trujillo, Trujillo 13011, Peru

Abstract

Biological models for cardiac regeneration and remodeling, along with the effects of cytokines or chemokines during the therapy with mesenchymal stem cells after a myocardial infarction, are of crucial importance for understanding the complex underlying mechanisms. This paper presents a mathematical model composed of three coupled partial differential equations that describes the dynamics of stem cells, nutrients and chemokines, highlighting the fundamental role of the chemokines during the myocardial tissue regeneration process. The system is solved numerically using mimetic difference operators and the MOLE library for MATLAB. The results show the tissue regeneration process in the necrotic part closest to the cell implantation area.

Funder

CONCYTEC-PROCIENCIA

Publisher

MDPI AG

Link

https://www.mdpi.com/2227-7390/12/13/1937/pdf

Reference28 articles.

1. Stem Cells in Regenerative Cardiology;Arbatli;Adv. Exp. Med. Biol.,2018

2. Cardiac regeneration: Current therapies-future concepts;Doppler;J. Thorac. Dis.,2013

3. Advances in stem cell therapy for cardiovascular disease (Review);Sun;Int. J. Mol. Med.,2016

4. Mechanisms of myocardial regeneration;Leri;Trends Cardiovasc. Med.,2011

5. Penn, M.S. (2007). Stem Cells and Myocardial Regeneration, Humana Press.