Hepatocellular Carcinoma: The Role of MicroRNAs

Author:

Khare Sharad,Khare Tripti,Ramanathan RaghuORCID,Ibdah Jamal A.ORCID

Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. HCC is diagnosed in its advanced stage when limited treatment options are available. Substantial morphologic, genetic and epigenetic heterogeneity has been reported in HCC, which poses a challenge for the development of a targeted therapy. In this review, we discuss the role and involvement of several microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma with a special emphasis on their possible role as a diagnostic and prognostic tool in the risk prediction, early detection, and treatment of hepatocellular carcinoma.

Funder

University of Missouri

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

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