Exploring the Therapeutic Potential of Royal Jelly in Metabolic Disorders and Gastrointestinal Diseases

Author:

El-Seedi Hesham R.123ORCID,Salama Suzy4ORCID,El-Wahed Aida A. Abd5ORCID,Guo Zhiming2ORCID,Di Minno Alessandro67ORCID,Daglia Maria67ORCID,Li Chuan8ORCID,Guan Xiao910,Buccato Daniele Giuseppe6,Khalifa Shaden A. M.11,Wang Kai12ORCID

Affiliation:

1. Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, P.O. Box 591, SE-751 24 Uppsala, Sweden

2. School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China

3. International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu University, Zhenjiang 210024, China

4. Indigenous Knowledge and Heritage Center, Ghibaish College of Science and Technology, Ghibaish 51111, Sudan

5. Department of Bee Research, Plant Protection Research Institute, Agricultural Research Centre, Giza 12627, Egypt

6. Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy

7. CEINGE-Biotecnologie Avanzate, Via Gaetano Salvatore 486, 80145 Naples, Italy

8. School of Food Science and Engineering, Hainan University, Haikou 570228, China

9. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

10. National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, Shanghai 200093, China

11. Psychiatry and Neurology Department, Capio Saint Göran’s Hospital, Sankt Göransplan 1, 112 19 Stockholm, Sweden

12. State Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China

Abstract

Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, etc., pose a substantial global health threat, with rising morbidity and mortality rates. Addressing these disorders is crucial, as conventional drugs often come with high costs and adverse effects. This review explores the potential of royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. This review’s focus is on investigating how RJ and its components impact conditions like diabetes mellitus, cardiovascular disease, and gastrointestinal illnesses. Evidence suggests that RJ serves as a complementary treatment for various health issues, notably demonstrating cholesterol- and glucose-lowering effects in diabetic rats. Specific RJ-derived metabolites, such as 10-hydroxy-2-decenoic acid (10-HDA), also known as the “Queen bee acid,” show promise in reducing insulin resistance and hyperglycemia. Recent research highlights RJ’s role in modulating immune responses, enhancing anti-inflammatory cytokines, and suppressing key inflammatory mediators. Despite these promising findings, further research is needed to comprehensively understand the mechanisms underlying RJ’s therapeutic effects.

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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