Comparative Antihyperglycemic and Antihyperlipidemic Effects of Lawsone Methyl Ether and Lawsone in Nicotinamide-Streptozotocin-Induced Diabetic Rats
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Published:2023-07-20
Issue:7
Volume:13
Page:863
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ISSN:2218-1989
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Container-title:Metabolites
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language:en
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Short-container-title:Metabolites
Author:
Khan Muhammad12, Shah Muhammad Ajmal3ORCID, Kamal Mustafa4ORCID, Ola Mohammad Shamsul5ORCID, Ali Mehboob6, Panichayupakaranant Pharkphoom17ORCID
Affiliation:
1. Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai 90112, Thailand 2. Department of Pharmacology, Federal Urdu University of Arts, Science and Technology, Karachi 75300, Pakistan 3. Department of Pharmacy, Hazara University, Mansehra 21300, Pakistan 4. Department of Zoology, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan 5. Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia 6. Senior Scientist Toxicology Invivotek Nexus, a Genesis Biotech Group LLC Company, 17 Black Forest RD, Hamilton, NJ 08690, USA 7. Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai 90112, Thailand
Abstract
Our previous study uncovered potent inhibitory effects of two naphthoquinones from Impatiens balsamina, namely lawsone methyl ether (2-methoxy-1,4-naphthoquinone, LME) and lawsone (2-hydroxy-1,4-naphthoquinone), against α-glucosidase. This gave us the insight to compare the hypoglycemic and hypolipidemic effects of LME and lawsone in high-fat/high-fructose-diet- and nicotinamide-streptozotocin-induced diabetic rats for 28 days. LME and lawsone at the doses of 15, 30, and 45 mg/kg, respectively, produced a substantial and dose-dependent reduction in the levels of fasting blood glucose (FBG), HbA1c, and food/water intake while boosting the insulin levels and body weights of diabetic rats. Additionally, the levels of total cholesterol (TC), triglycerides (TGs), high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), aspartate transaminase (AST), alanine transaminase (ALT), creatinine, and blood urea nitrogen (BUN) in diabetic rats were significantly normalized by LME and lawsone, without affecting the normal rats. LME at a dose of 45 mg/kg exhibited the most potent antihyperglycemic and antihyperlipidemic effects, which were significantly comparable to glibenclamide but higher than those of lawsone. Furthermore, the toxicity evaluation indicated that both naphthoquinones were entirely safe for use in rodent models at doses ≤ 50 mg/kg. Therefore, the remarkable antihyperglycemic and antihyperlipidemic potentials of LME make it a promising option for future drug development.
Funder
Prince of Songkla University, Thailand King Saud University, Riyadh, Saudi Arabia
Subject
Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism
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