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Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer

Published:2023-09-09 Issue:9 Volume:14 Page:466
ISSN:2079-4983
Container-title:Journal of Functional Biomaterials
language:en
Short-container-title:JFB

Author:

Crintea Andreea¹,Constantin Anne-Marie²,Motofelea Alexandru C.³^ORCID,Crivii Carmen-Bianca²^ORCID,Velescu Maria A.⁴,Coșeriu Răzvan L.⁵^ORCID,Ilyés Tamás¹,Crăciun Alexandra M.¹^ORCID,Silaghi Ciprian N.¹^ORCID

Affiliation:

1. Department of Molecular Sciences, University of Medicine and Pharmacy “Iuliu Hațieganu”, 400349 Cluj-Napoca, Romania

2. Department of Morphological Sciences, University of Medicine and Pharmacy “Iuliu Hațieganu”, 400349 Cluj-Napoca, Romania

3. Department of Internal Medicine, University of Medicine and Pharmacy “Victor Babeș”, 300041 Timișoara, Romania

4. Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hațieganu”, 400349 Cluj-Napoca, Romania

5. Department of Microbiology, University of Medicine, Pharmacy, Science and Technology “George Emil Palade”, 540142 Târgu-Mureș, Romania

Abstract

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. Despite advances in treatment, the prognosis remains poor, highlighting the need for novel therapeutic strategies. The present review explores the potential of targeted epidermal growth factor receptor (EGFR) nanotherapy as an alternative treatment for NSCLC, showing that EGFR-targeted nanoparticles are efficiently taken up by NSCLC cells, leading to a significant reduction in tumor growth in mouse models. Consequently, we suggest that targeted EGFR nanotherapy could be an innovative treatment strategy for NSCLC; however, further studies are needed to optimize the nanoparticles and evaluate their safety and efficacy in clinical settings and human trials.

Funder

Increasing the Performance of Scientific Research, Supporting Excellence in Medical Research and Innovation

Publisher

MDPI AG

Subject

Biomedical Engineering,Biomaterials

Link

https://www.mdpi.com/2079-4983/14/9/466/pdf

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