Implementation and Assessment of a Laparotomy-Assisted Three-Port Fetoscopic Spina Bifida Repair Program

Author:

Keil Corinna1ORCID,Köhler Siegmund1,Sass Benjamin2,Schulze Maximilian3,Kalmus Gerald4,Belfort Michael56,Schmitt Nicolas4,Diehl Daniele7,King Alice68,Groß Stefanie7,Sutton Caitlin D.9,Joyeux Luc68,Wege Mirjam10ORCID,Nimsky Christopher2ORCID,Whitehead Wiliam E.611,Uhl Eberhard12ORCID,Huisman Thierry A. G. M.13,Neubauer Bernd A.7,Weber Stefanie14ORCID,Hummler Helmut10,Axt-Fliedner Roland15,Bedei Ivonne15ORCID

Affiliation:

1. Department of Prenatal Medicine and Fetal Therapy, Philipps University, 35043 Marburg, Germany

2. Department of Neurosurgery, Philipps University, 35043 Marburg, Germany

3. Department of Neuroradiology, Philipps University, 35043 Marburg, Germany

4. Department of Anesthesiology and Intensive Care Medicine, Philipps University, 35043 Marburg, Germany

5. Department of Obstetrics and Gynecology, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA

6. Texas Children’s Fetal Center, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA

7. Department of Pediatric Neurology, Justus-Liebig University Giessen, 35392 Giessen, Germany

8. Division of Pediatric Surgery, Department of Surgery, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA

9. Department of Pediatric Anesthesiology, Perioperative, and Pain Medicine, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA

10. Division of Neonatology, University Children’s Hospital Marburg, 35043 Marburg, Germany

11. Department of Neurosurgery, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA

12. Department of Neurosurgery, Justus-Liebig University, 35390 Giessen, Germany

13. Edward B. Singleton Department of Radiology, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA

14. Division of Pediatric Nephrology and Transplantation, University Children’s Hospital Marburg, 35043 Marburg, Germany

15. Department of Prenatal Medicine and Fetal Therapy, Justus-Liebig University Giessen, 35390 Giessen, Germany

Abstract

Open spina bifida (OSB) is a congenital, non-lethal malformation with multifactorial etiology. Fetal therapy can be offered under certain conditions to parents after accurate prenatal diagnostic and interdisciplinary counseling. Since the advent of prenatal OSB surgery, various modifications of the original surgical techniques have evolved, including laparotomy-assisted fetoscopic repair. After a two-year preparation time, the team at the University of Giessen and Marburg (UKGM) became the first center to provide a three-port, three-layer fetoscopic repair of OSB via a laparotomy-assisted approach in the German-speaking area. We point out that under the guidance of experienced centers and by intensive multidisciplinary preparation and training, a previously described and applied technique could be transferred to a different setting.

Publisher

MDPI AG

Subject

General Medicine

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