Abstract
The steroidogenic cells in the testicle, Leydig cells, located in the interstitial compartment, play a vital role in male reproductive tract development, maintenance of proper spermatogenesis, and overall male reproductive function. Therefore, their dysfunction can lead to all sorts of testicular pathologies. Spermatogenesis failure, manifested as azoospermia, is often associated with defective Leydig cell activity. Spermatogenic failure is the most severe form of male infertility, caused by disorders of the testicular parenchyma or testicular hormone imbalance. This review covers current progress in knowledge on Leydig cells origin, structure, and function, and focuses on recent advances in understanding how Leydig cells contribute to the impairment of spermatogenesis.
Funder
National Science Center
Medical University of Lodz
Subject
Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics
Reference303 articles.
1. Testis physiology—Overview and histology;Lara,2018
2. Building the mammalian testis: origins, differentiation, and assembly of the component cell populations
3. Male reproductive system;Ross,2015
4. Functional Anatomy and Histology of the Testis;Fietz,2017
5. The male reproductive system;Jones,2014
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