The Role of the Adenosine System on Emotional and Cognitive Disturbances Induced by Ethanol Binge Drinking in the Immature Brain and the Beneficial Effects of Caffeine

Author:

Pinheiro Bruno Gonçalves123,Luz Diandra Araújo2ORCID,Cartágenes Sabrina de Carvalho123,Fernandes Luanna de Melo Pereira3ORCID,Farias Sarah Viana2ORCID,Kobayashi Natália Harumi Correa2,Fontes-Júnior Enéas Andrade2ORCID,Ferreira Samira G.4,Cunha Rodrigo A.45ORCID,Prediger Rui Daniel6,Maia Cristiane do Socorro Ferraz127ORCID

Affiliation:

1. Neurosciences and Cellular Biology Post Graduation Program, Biological Sciences Institute, Federal University of Pará, Belém 66075-110, PA, Brazil

2. Behavioral and Inflammatory Pharmacology Laboratory, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-110, PA, Brazil

3. Physiological and Morphological Sciences Department, Biological and Health Science Centre, State University of Pará, Belém 66050-540, PA, Brazil

4. CNC-Center for Neurosciences and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal

5. Faculty of Medicine, University of Coimbra, 3004-531 Coimbra, Portugal

6. Department of Pharmacology, Centre of Biological Science, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil

7. Laboratório de Farmacologia da Inflamação e do Comportamento, Instituto de Ciências da Saúde, Universidade Federal do Pará, Rua Augusto Corrêa 1, Belém 66075-900, PA, Brazil

Abstract

Binge drinking intake is the most common pattern of ethanol consumption by adolescents, which elicits emotional disturbances, mainly anxiety and depressive symptoms, as well as cognitive alterations. Ethanol exposure may act on the adenosine neuromodulation system by increasing adenosine levels, consequently increasing the activation of adenosine receptors in the brain. The adenosine modulation system is involved in the control of mood and memory behavior. However, there is a gap in the knowledge about the exact mechanisms related to ethanol exposure’s hazardous effects on the immature brain (i.e., during adolescence) and the role of the adenosine system thereupon. The present review attempts to provide a comprehensive picture of the role of the adenosinergic system on emotional and cognitive disturbances induced by ethanol during adolescence, exploring the potential benefits of caffeine administration in view of its action as a non-selective antagonist of adenosine receptors.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq/Brazil

Center for Neurosciences and Cell Biology, Faculty of Medicine, University of Coimbra, Portugal

Federal University of Pará (PROPESP, UFPA, Brazil)

La Caixa Foundation

Centro 2020

FCT

Publisher

MDPI AG

Reference181 articles.

1. National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2022, September 01). Council Approves Definition of Binge Drinking, Available online: https://pubs.niaaa.nih.gov/publications/Newsletter/winter2004/Newsletter_Number3.pdf.

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4. Acute Effects of Ethanol on Hippocampal Long-Term Potentiation and Long-Term Depression Are Mediated by Different Mechanisms;Izumi;Neuroscience,2005

5. Effects of Adolescent Ethanol Exposure on Ethanol Consumption in Adult Rats;Slawecki;Alcohol,2002

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