Role of microRNAs in Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension-Reference-Cited by-同舟云学术

Role of microRNAs in Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension

Published:2023-04-03 Issue:7 Volume:24 Page:6656
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Pugnaloni Flaminia¹^ORCID,Capolupo Irma¹^ORCID,Patel Neil²,Giliberti Paola¹,Dotta Andrea¹^ORCID,Bagolan Pietro³⁴,Kipfmueller Florian⁵^ORCID

Affiliation:

1. Neonatal Intensive Care Unit, Bambino Gesù Children Hospital, Instituti di Ricovero e Cura a Carattere Scietifico (IRCCS), 00165 Rome, Italy

2. Department of Neonatology, The Royal Hospital for Children, Glasgow G51 4TF, UK

3. Area of Fetal, Neonatal and Cardiological Sciences Children’s Hospital Bambino Gesù-Research Institute, 00165 Rome, Italy

4. Department of Systems Medicine, University of Rome “Tor Vergata”, 00165 Rome, Italy

5. Department of Neonatology and Pediatric Intensive Care, Children’s Hospital, University of Bonn, 53127 Bonn, Germany

Abstract

Epigenetic regulators such as microRNAs (miRNAs) have a key role in modulating several gene expression pathways and have a role both in lung development and function. One of the main pathogenetic determinants in patients with congenital diaphragmatic hernia (CDH) is pulmonary hypertension (PH), which is directly related to smaller lung size and pulmonary microarchitecture alterations. The aim of this review is to highlight the importance of miRNAs in CDH-related PH and to summarize the results covering this topic in animal and human CDH studies. The focus on epigenetic modulators of CDH-PH offers the opportunity to develop innovative diagnostic tools and novel treatment modalities, and provides a great potential to increase researchers’ understanding of the pathophysiology of CDH.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/7/6656/pdf

Reference67 articles.

1. Prevalence and Risk Factors for Congenital Diaphragmatic Hernia: A Global View;Paoletti;J. Pediatr. Surg.,2020

2. Mortality in Congenital Diaphragmatic Hernia: A Multicenter Registry Study of Over 5000 Patients Over 25 Years;Gupta;Ann. Surg.,2021

3. Congenital Diaphragmatic Hernia Defect Size and Infant Morbidity at Discharge;Putnam;Pediatrics,2016

4. Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension;Gupta;Semin. Perinatol.,2020

5. Lung Hypoplasia in Congenital Diaphragmatic Hernia a Quantitative Study of Airway, Artery, and Alveolar Development;Kitagawa;Br. J. Surg.,1971