The Prognostic and Diagnostic Value of [18F]FDG PET/CT in Untreated Laryngeal Carcinoma

Author:

Al-Ibraheem Akram12ORCID,Abdlkadir Ahmed Saad1,Al-Adhami Dhuha1,Hejleh Taher Abu3,Mansour Asem4,Mohamad Issa5ORCID,Juweid Malik E.2,Al-Rasheed Ula1,Al-Hajaj Nabeela1,Laban Dima Abu4,Estrada-Lobato Enrique6,Saraireh Omar7

Affiliation:

1. Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Al-Jubeiha, Amman 11941, Jordan

2. Department of Radiology and Nuclear Medicine, Division of Nuclear Medicine, University of Jordan, Amman 11942, Jordan

3. Department of Medical Oncology, King Hussein Cancer Center, Amman 11941, Jordan

4. Department of Diagnostic Radiology, King Hussein Cancer Center, Amman 11941, Jordan

5. Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan

6. Nuclear Medicine and Diagnostic Section, Division of Human Health, International Atomic Energy Agency, 1220 Vienna, Austria

7. Department of Surgical Oncology, King Hussein Cancer Center, Amman 11941, Jordan

Abstract

This study aims to determine the diagnostic accuracy of staging PET/CT and neck MRI in patients with laryngeal carcinoma and to assess the value of PET/CT in predicting progression-free survival (PFS) and overall survival (OS). Sixty-eight patients who had both modalities performed before treatment between 2014 and 2021 were included in this study. The sensitivity and specificity of PET/CT and MRI were evaluated. PET/CT had 93.8% sensitivity, 58.3% specificity, and 75% accuracy for nodal metastasis, whereas MRI had 68.8%, 61.1%, and 64.7% accuracy, respectively. At a median follow-up of 51 months, 23 patients had developed disease progression and 17 patients had died. Univariate-survival analysis revealed all utilized PET parameters as significant prognostic factors for OS and PFS (p-value < 0.03 each). In multivariate analysis, metabolic-tumor volume (MTV) and total lesion glycolysis (TLG) predicted better PFS (p-value < 0.05 each). In conclusion, PET/CT improves the accuracy of nodal staging in laryngeal carcinoma over neck MRI and adds to the prognostication of survival outcomes through the use of several PET metrics.

Publisher

MDPI AG

Subject

General Medicine

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