Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds
-
Published:2023-07-31
Issue:8
Volume:11
Page:324
-
ISSN:2304-6740
-
Container-title:Inorganics
-
language:en
-
Short-container-title:Inorganics
Author:
Oguzkan Sibel Bayil1ORCID, Turkez Hasan2, Ugras Halil Ibrahim3, Tatar Arzu4, Mardinoglu Adil56ORCID
Affiliation:
1. Department of Medical Services and Techniques, Vocational School of Health Services, University of Gaziantep, Gaziantep 27410, Turkey 2. Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum 25040, Turkey 3. Department of Chemistry, Arts and Science Faculty, Düzce University, Düzce 81620, Turkey 4. Department of Otorhinolaryngology Diseases, Faculty of Medicine, Atatürk University, Erzurum 25040, Turkey 5. Science for Life Laboratory, KTH-Royal Institute of Technology, 11428 Stockholm, Sweden 6. Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London WC2R 2LS, UK
Abstract
In this study, the biological properties of novel borenium and borinium compounds in terms of their oxidative, genotoxic, and cytotoxic effects were assessed on cultured human peripheral blood cells, as well as several types of cancer cells. Our results revealed that the borinium compounds yielded the best results in terms of supporting total antioxidant capacity (TAC). In fact, borenium 1, borenium 2, borenium 3, borinium 4, and borinium 5 compounds elevated TAC levels of cultured human blood cells at rates of 42.8%, 101.5%, 69.8%, 33.3%, and 49.2%, respectively. There were no statistically significant differences (p > 0.05) between the negative control and the groups treated with all borinium and borenium concentrations from the micronucleus (MN) and chromosome aberration (CA) assays, demonstrating the non-genotoxic effects. Moreover, borenium 1 (60.7% and 50.7%), borenium 2 (70.4% and 57.2%), borenium 3 (53.1% and 45.2%), borinium 4 (55.1% and 48.1%), and borinium 5 (51.0% and 36.1%) minimized the mitomycin C(MMC)-induced genotoxic damages at different rates as determined using CA and MN assays, respectively. Again, it was found that the borinium compounds exhibited higher cytotoxic activity on cancer cells when compared to borenium compounds. Consequently, in light of our in vitro findings, it was suggested that the novel borinium and borenium compounds could be used safely in pharmacology, cosmetics, and various medical fields due to their antioxidant and non-genotoxic features, as well as their cytotoxicity potential on cancer cells.
Subject
Inorganic Chemistry
Reference70 articles.
1. Turkez, H., Yıldırım, S., Sahin, E., Arslan, M.E., Emsen, B., Tozlu, O.O., Alak, G., Ucar, A., Tatar, A., and Hacimuftuoglu, A. (2022). Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study. Toxics, 10. 2. Feng, D., Lin, H., Jiang, L., Wang, Z., Sun, Y., Zhou, Z., de Clercq, E., Pannecouque, C., Kang, D., and Zhan, P. (2022). Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. Molecules, 27. 3. A Novel Amphotericin B Hydrogel Composed of Poly(Vinyl Alcohol)/Borate Complex for Ophthalmic Formulation;Banshoya;Chem. Pharm. Bull.,2023 4. Design and Synthesis of Boron-Containing ALK Inhibitor with Favorable In Vivo Efficacy;Ren;Bioorg. Med. Chem.,2022 5. Coghi, P.S., Zhu, Y., Xie, H., Hosmane, N.S., and Zhang, Y. (2021). Organoboron Compounds: Effective Antibacterial and Antiparasitic Agents. Molecules, 26.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|