Open and Closed Triple Inhaler Therapy in Patients with Uncontrolled Asthma-Reference-Cited by-同舟云学术

Open and Closed Triple Inhaler Therapy in Patients with Uncontrolled Asthma

Published:2023-07-04 Issue:4 Volume:91 Page:288-300
ISSN:2543-6031
Container-title:Advances in Respiratory Medicine
language:en
Short-container-title:ARM

Author:

Kotoulas Serafeim-Chrysovalantis¹^ORCID,Tsiouprou Ioanna²^ORCID,Domvri Kalliopi³^ORCID,Dontsi Polyxeni⁴,Pataka Athanasia⁵^ORCID,Porpodis Konstantinos²^ORCID

Affiliation:

1. ICU, General Hospital of Thessaloniki “Hippokration”, 49th Kostantinoupoleos Street, 57642 Thessaloniki, Greece

2. Pulmonary Clinic of Aristotle University of Thessaloniki, General Hospital of Thessaloniki “Georgios Papanikolaou”, Leoforos Papanikolaou, Exohi, 57010 Thessaloniki, Greece

3. Laboratory of Histology-Embryology, Medical School, Aristotle University of Thessaloniki, Leoforos Agiou Dimitriou, 54124 Thessaloniki, Greece

4. 2nd University Department of Respiratory Medicine, Attikon Hospital, 1st Rimini Street, Haidari,12462 Athens, Greece

5. Respiratory Failure Clinic of Aristotle University of Thessaloniki, General Hospital of Thessaloniki “Georgios Papanikolaou”, Leoforos Papanikolaou, Exohi, 57010 Thessaloniki, Greece

Abstract

Long-acting muscarinic antagonists (LAMAs) are a class of inhalers that has recently been included as add-on therapy in the GINA guidelines, either in a single inhaler device with inhaled corticosteroids plus long-acting β2-agonists (ICS + LABA) (closed triple inhaler therapy) or in a separate one (open triple inhaler therapy). This review summarizes the existing evidence on the addition of LAMAs in patients with persistently uncontrolled asthma despite ICS + LABA treatment based on clinical efficacy in the reduction of asthma symptoms and exacerbations, the improvement in lung function, and its safety profile.

Publisher

MDPI AG

Subject

Pulmonary and Respiratory Medicine

Link

https://www.mdpi.com/2543-6031/91/4/23/pdf

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1. Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA;Pharmaceuticals;2023-11-14