New Developments on Growth Factors, Exosomes, and Single Cell RNA-Sequencing for Regeneration of the Intervertebral Disc

Author:

Gantenbein Benjamin12ORCID

Affiliation:

1. Tissue Engineering for Orthopaedics & Mechanobiology (TOM), Bone & Joint Program, Department for BioMedical Research (DBMR), Faculty of Medicine, University of Bern, CH-3008 Bern, Switzerland

2. Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, Medical Faculty, University of Bern, CH-3010 Bern, Switzerland

Abstract

Low back pain (LBP) is the number one cause of disability worldwide, with incidences increasing exponentially [...]

Funder

Swiss National Science Foundation

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

Reference33 articles.

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2. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392, 1789–1858.

3. Can We Increase Our Health Span?;Phys. Med. Rehabil. Clin. N. Am.,2017

4. Rohanifar, M., Clayton, S.W., Easson, G.W., Patil, D.S., Lee, F., Jing, L., Barcellona, M.N., Speer, J.E., Stivers, J.J., and Tang, S.Y. (2022). Single Cell RNA-Sequence Analyses Reveal Uniquely Expressed Genes and Heterogeneous Immune Cell Involvement in the Rat Model of Intervertebral Disc Degeneration. Appl. Sci., 12.

5. CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration;Liu;J. Biol. Eng.,2018

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