Targeting Breast Cancer: An Overlook on Current Strategies

Author:

Iacopetta Domenico1ORCID,Ceramella Jessica1ORCID,Baldino Noemi2ORCID,Sinicropi Maria1ORCID,Catalano Alessia3ORCID

Affiliation:

1. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy

2. Laboratory of Rheology and Food Engineering, Department of Information, Modeling, Electronics and System Engineering (D.I.M.E.S.), University of Calabria, 87036 Arcavacata di Rende, Italy

3. Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70126 Bari, Italy

Abstract

Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause of cancer death among women worldwide. Globally, BC is the second most frequent cancer and first most frequent gynecological one, affecting women with a relatively low case-mortality rate. Surgery, radiotherapy, and chemotherapy are the main treatments for BC, even though the latter are often not aways successful because of the common side effects and the damage caused to healthy tissues and organs. Aggressive and metastatic BCs are difficult to treat, thus new studies are needed in order to find new therapies and strategies for managing these diseases. In this review, we intend to give an overview of studies in this field, presenting the data from the literature concerning the classification of BCs and the drugs used in therapy for the treatment of BCs, along with drugs in clinical studies.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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