Affiliation:
1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China
2. Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing 100081, China
Abstract
The progress of space science and technology has ushered in a new era for humanity’s exploration of outer space. Recent studies have indicated that the aerospace special environment including microgravity and space radiation poses a significant risk to the health of astronauts, which involves multiple pathophysiological effects on the human body as well on tissues and organs. It has been an important research topic to study the molecular mechanism of body damage and further explore countermeasures against the physiological and pathological changes caused by the space environment. In this study, we used the rat model to study the biological effects of the tissue damage and related molecular pathway under either simulated microgravity or heavy ion radiation or combined stimulation. Our study disclosed that ureaplasma-sensitive amino oxidase (SSAO) upregulation is closely related to the systematic inflammatory response (IL-6, TNF-α) in rats under a simulated aerospace environment. In particular, the space environment leads to significant changes in the level of inflammatory genes in heart tissues, thus altering the expression and activity of SSAO and causing inflammatory responses. The detailed molecular mechanisms have been further validated in the genetic engineering cell line model. Overall, this work clearly shows the biological implication of SSAO upregulation in microgravity and radiation-mediated inflammatory response, providing a scientific basis or potential target for further in-depth investigation of the pathological damage and protection strategy under a space environment.
Funder
National Natural Science Foundation of China
Beijing Institute of Technology Research Fund Program for Young Scholars
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference48 articles.
1. Heart disease and stroke statistics—2020 update: A report from the American Heart Association;Virani;Circulation,2020
2. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications;Zheng;Nat. Rev. Endocrinol.,2018
3. A century of Alzheimer’s disease;Goedert;Science,2006
4. Unzeta, M., Hernàndez-Guillamon, M., Sun, P., and Solé, M. (2021). SSAO/VAP-1 in cerebrovascular disorders: A potential therapeutic target for stroke and Alzheimer’s disease. Int. J. Mol. Sci., 22.
5. Inflammation and cancer;Coussens;Nature,2002