Bioactive Alpha-Pyrone and Phenolic Glucosides from the Marine-Derived Metarhizium sp. P2100
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Published:2022-12-23
Issue:1
Volume:9
Page:28
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ISSN:2309-608X
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Container-title:Journal of Fungi
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language:en
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Short-container-title:JoF
Author:
Ma Zhong-Lian,Yu Zhi-Pu,Zheng Yao-Yao,Han Na,Zhang Ya-Hui,Song Shu-Yue,Mao Jun-Qiu,Li Jiao-Jiao,Yao Guang-Shan,Wang Chang-Yun
Abstract
Glycoside compounds have attracted great interest due to their remarkable and multifarious bioactivities. In this study, four hitherto unknown 4-methoxy-β-D-glucosyl derivatives were obtained and identified from the marine-derived fungus Metarhizium sp. P2100, including three alpha-pyrone glycosides (1–3) and one phenolic glycoside (4). Their planar structures were elucidated by comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS. The absolute configurations of 1–3 were determined by a single-crystal X-ray crystallographic experiment, a comparison of the experimental, and a calculated electronic circular dichroism (ECD) spectra, respectively. Compounds 2 and 3 are a pair of rare epimeric pyranoside glycosides at C-7 with a core of aglycone as 2H-pyrone. Compounds 1–4 exhibited weak anti-inflammatory activities. In particular, compounds 1–3 displayed inhibitory activities against α-amylase, showing a potential for the development of a new α-amylase inhibitor for controlling diabetes.
Funder
National Natural Science Foundations of China
Natural Science Foundation of Fujian Province
Shandong Provincial Natural Science Foundation (Major Basic Research Projects
Subject
Plant Science,Ecology, Evolution, Behavior and Systematics,Microbiology (medical)