Proteomic and Metabolomic Analyses of the Blood Samples of Highly Trained Athletes
Author:
Malsagova Kristina A.1ORCID, Kopylov Arthur T.1ORCID, Pustovoyt Vasiliy I.2ORCID, Balakin Evgenii I.2ORCID, Yurku Ksenia A.2, Stepanov Alexander A.1ORCID, Kulikova Liudmila I.1, Rudnev Vladimir R.1, Kaysheva Anna L.1ORCID
Affiliation:
1. Institute of Biomedical Chemistry, 119121 Moscow, Russia 2. State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 119435 Moscow, Russia
Abstract
High exercise loading causes intricate and ambiguous proteomic and metabolic changes. This study aims to describe the dataset on protein and metabolite contents in plasma samples collected from highly trained athletes across different sports disciplines. The proteomic and metabolomic analyses of the plasma samples of highly trained athletes engaged in sports disciplines of different intensities were carried out using HPLC-MS/MS. The results are reported as two datasets (proteomic data in a derived mgf-file and metabolomic data in processed format), each containing the findings obtained by analyzing 93 mass spectra. Variations in the protein and metabolite contents of the biological samples are observed, depending on the intensity of training load for different sports disciplines. Mass spectrometric proteomic and metabolomic studies can be used for classifying different athlete phenotypes according to the intensity of sports discipline and for the assessment of the efficiency of the recovery period.
Subject
Information Systems and Management,Computer Science Applications,Information Systems
Reference35 articles.
1. Malsagova, K.A., Butkova, T.V., Kopylov, A.T., Izotov, A.A., Rudnev, V.R., Klyuchnikov, M.S., Stepanov, A.A., and Kaysheva, A.L. (2021). Molecular Portrait of an Athlete. Diagnostics, 11. 2. Sportomics: Metabolomics Applied to Sports. The New Revolution?;Bongiovanni;Eur. Rev. Med. Pharmacol. Sci.,2019 3. Nieman, D.C., Gillitt, N.D., Knab, A.M., Shanely, R.A., Pappan, K.L., Jin, F., and Lila, M.A. (2013). Influence of a Polyphenol-Enriched Protein Powder on Exercise-Induced Inflammation and Oxidative Stress in Athletes: A Randomized Trial Using a Metabolomics Approach. PLoS ONE, 8. 4. 1H NMR-Based Metabonomic Investigation of the Effect of Two Different Exercise Sessions on the Metabolic Fingerprint of Human Urine;Pechlivanis;J. Proteome Res.,2010 5. Nieman, D.C., Gillitt, N.D., Henson, D.A., Sha, W., Shanely, R.A., Knab, A.M., Cialdella-Kam, L., and Jin, F. (2012). Bananas as an Energy Source during Exercise: A Metabolomics Approach. PLoS ONE, 7.
|
|