Core–Shell Particles: From Fabrication Methods to Diverse Manipulation Techniques

Author:

Yadav Ajeet Singh1ORCID,Tran Du Tuan1ORCID,Teo Adrian J. T.2,Dai Yuchen1ORCID,Galogahi Fariba Malekpour1,Ooi Chin Hong1ORCID,Nguyen Nam-Trung1ORCID

Affiliation:

1. Queensland Micro- and Nanotechnology Centre, Griffith University, 170 Kessels Road, Nathan, QLD 4111, Australia

2. HP-NTU Digital Manufacturing Corporate Lab, Nanyang Technological University, Singapore 637460, Singapore

Abstract

Core–shell particles are micro- or nanoparticles with solid, liquid, or gas cores encapsulated by protective solid shells. The unique composition of core and shell materials imparts smart properties on the particles. Core–shell particles are gaining increasing attention as tuneable and versatile carriers for pharmaceutical and biomedical applications including targeted drug delivery, controlled drug release, and biosensing. This review provides an overview of fabrication methods for core–shell particles followed by a brief discussion of their application and a detailed analysis of their manipulation including assembly, sorting, and triggered release. We compile current methodologies employed for manipulation of core–shell particles and demonstrate how existing methods of assembly and sorting micro/nanospheres can be adopted or modified for core–shell particles. Various triggered release approaches for diagnostics and drug delivery are also discussed in detail.

Funder

Australian Research Council

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering

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