Affiliation:
1. Neurobiota Research Center, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
Abstract
Porphyromonas gingivalis (PG) is closely involved in the outbreak of periodontitis and cognitive impairment (CI). Herein, we examined the effects of anti-inflammatory Lactobacillus pentosus NK357 and Bifidobacterium bifidum NK391 on PG- or its extracellular vesicles (pEVs)-induced periodontitis and CI in mice. Oral administration of NK357 or NK391 significantly decreased PG-induced tumor necrosis factor (TNF)-α, receptor activator of nuclear factors κB (RANK), and RANK ligand (RANKL) expression, gingipain (GP)+lipopolysaccharide (LPS)+ and NF-κB+CD11c+ populations, and PG 16S rDNA level in the periodontal tissue. Their treatments also suppressed PG-induced CI -like behaviors, TNF-α expression and NF-κB-positive immune cells in the hippocampus and colon, while PG-suppressed hippocampal BDNF and N-methyl-D-aspartate receptor (NMDAR) expression increased. The combination of NK357 and NK391 additively alleviated PG- or pEVs-induced periodontitis, neuroinflammation, CI-like behaviors, colitis, and gut microbiota dysbiosis and increased PG- or pEVs-suppressed BDNF and NMDAR expression in the hippocampus. In conclusion, NK357 and NK391 may alleviate periodontitis and dementia by regulating NF-κB, RANKL/RANK, and BDNF-NMDAR signaling and gut microbiota.
Funder
National Research Foundation of Korea
Ministry of Food and Drug Safety
Reference39 articles.
1. Porphyromonas gingivalis: An overview of periodontopathic pathogen below the gum line;How;Front Microbiol.,2016
2. Porphyromonas gingivalis as a risk factor to Alzheimer’s disease: A systematic review;Elwishahy;J. Alzheimers Dis. Rep.,2021
3. Periodontal disease and eriodontal disease-related bacteria involved in the pathogenesis of Alzheimer’s disease;Matsushita;J. Inflamm. Res.,2020
4. Guo, H., Chang, S., Pi, X., Hua, F., Jiang, H., Liu, C., and Du, M. (2021). The effect of periodontitis on dementia and cognitive impairment: A meta-analysis. Int. J. Environ Res. Public Health, 18.
5. The role of gingipains in the pathogenesis of periodontal disease;Imamura;J. Periodontol.,2003
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