Prospects of Using Chitosan-Based Biopolymers in the Treatment of Peripheral Nerve Injuries

Author:

Zhang Meng12ORCID,An Heng3,Zhang Fengshi12ORCID,Jiang Haoran12,Wan Teng12ORCID,Wen Yongqiang3ORCID,Han Na12,Zhang Peixun12

Affiliation:

1. Department of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, China

2. Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Beijing 100044, China

3. Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, School of Chemistry & Biological Engineering, University of Science & Technology Beijing, Beijing 100083, China

Abstract

Peripheral nerve injuries are common neurological disorders, and the available treatment options, such as conservative management and surgical repair, often yield limited results. However, there is growing interest in the potential of using chitosan-based biopolymers as a novel therapeutic approach to treating these injuries. Chitosan-based biopolymers possess unique characteristics, including biocompatibility, biodegradability, and the ability to stimulate cell proliferation, making them highly suitable for repairing nerve defects and promoting nerve regeneration and functional recovery. Furthermore, these biopolymers can be utilized in drug delivery systems to control the release of therapeutic agents and facilitate the growth of nerve cells. This comprehensive review focuses on the latest advancements in utilizing chitosan-based biopolymers for peripheral nerve regeneration. By harnessing the potential of chitosan-based biopolymers, we can pave the way for innovative treatment strategies that significantly improve the outcomes of peripheral nerve injury repair, offering renewed hope and better prospects for patients in need.

Funder

National Natural Science Foundation of China

Beijing National Science Foundation

Peking University People’s Hospital Research and Development Fund

Key Laboratory of Trauma and Neural Regeneration

Ministry of Education of China

National Center for Trauma Medicine

Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing

Excellent Doctoral Graduate Innovation Foundation of Peking University Health Science Center

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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