The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced Carcinogenesis
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Published:2023-08-10
Issue:16
Volume:24
Page:12623
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Torres Wheeler1, Pérez José Luis1ORCID, Díaz María P.1, D’Marco Luis2ORCID, Checa-Ros Ana2ORCID, Carrasquero Rubén1, Angarita Lissé3ORCID, Gómez Yosselin1, Chacín Maricarmen4, Ramírez Paola1, Villasmil Nelson1, Durán-Agüero Samuel5, Cano Clímaco1, Bermúdez Valmore4ORCID
Affiliation:
1. Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela 2. Grupo de Investigación en Enfermedades Cardiorrenales y Metabólicas, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain 3. Escuela de Nutrición y Dietética, Facultad de Medicina, Universidad Andres Bello, Concepción 4260000, Chile 4. Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080022, Colombia 5. Facultad de Ciencias Para el Cuidado de la Salud, Universidad San Sebastián, Los Leones 8420524, Chile
Abstract
Cancer is a process involving cell mutation, increased proliferation, invasion, and metastasis. Over the years, this condition has represented one of the most concerning health problems worldwide due to its significant morbidity and mortality. At present, the incidence of cancer continues to grow exponentially. Thus, it is imperative to open new avenues in cancer research to understand the molecular changes driving DNA transformation, cell-to-cell interaction derangements, and immune system surveillance decay. In this regard, evidence supports the relationship between chronic inflammation and cancer. In light of this, a group of bioactive lipids derived from polyunsaturated fatty acids (PUFAs) may have a position as novel anti-inflammatory molecules known as the specialized pro-resolving mediators (SPMs), a group of pro-resolutive inflammation agents that could improve the anti-tumor immunity. These molecules have the potential role of chemopreventive and therapeutic agents for various cancer types, and their effects have been documented in the scientific literature. Thus, this review objective centers around understanding the effect of SPMs on carcinogenesis and their potential therapeutic effect.
Funder
Universidad Simón Bolívar, Vicerrectoría de Investigación, Extensión e Innovación, Barranquilla, Colombia Consejo de Desarrollo Científico, Humanístico y Tecnológico (CONDES), University of Zulia Fundacite-Zulia
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
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